Clinical Studies
SMILE Study 2023
This study reflects the latest product improvements for patient and physician ease of use.
USA Parkinson Study Group - Multicenter Clinical Study 2022
EarStim was tested for the dose/duration of use in a pilot clinical trial in eight different centres in the USA.
The short EARSTIM stimulation treatment had the largest aggregate motor score improvement.
EARSTIM treatments resulted in
“ Motor improvements greater than the Minimum Clinically Important Difference (MCID) at multiple time points ”,
whereas active sham treatment did not.
The study results are published as a SPOTLIGHT article in Parkinsonism and Related Disorders Journal.
Click on the journal cover on the left to access the article.
wEARABLE MOTION CAPTURE Study 2019
Provides immediate relief and accelerates impact of levodopa
The clinical trial conducted to objectively measure the effects of using EarStim on the motor symptoms of Parkinson’s patients has been conducted with a wearable motion capture system.
The Earstim group demonstrated faster improvement in motor symptoms in comparison to oral medication in Parkinson’s patients. The combined use of medication and Earstim demonstrated a more effective outcome than the medication alone.
The findings of the clinical trial were published in the Frontiers in Neurology journal. Please click here to access the article.
Mechanism of Action Study 2018
fMRI analysis demonstrates the modulation of multiple motor control regions of the brain which are all associated with PD pathophysiology and motor symptoms
EarStim’s mechanism of action in the brain was studied in a clinical trial. The patients’ fMRI images before and after the stimulation applied by EarStim were assessed to observe the changes.
Short-term Efficacy Study 2017
Demonstrates sustained UPDRS improvement at 50 minutes
The clinical trial was conducted with 24 patients studied in a sham-controlled protocol. The efficacy and safety of EarStim in short-term use are demonstrated. EarStim demonstrated both statistically and clinically meaningful effects on alleviating the motor symptoms of Parkinson’s disease. Furthermore, no side effects were observed while wearing the device. The results of this research were published in an article in the journal Frontiers in Human Neuroscience. Please click here to access the article.
2017
Short-Term
Efficacy Study
2018
Mechanism of
Action Study
2019
Motion Capture Study
2020
Pandemic
2021
Pandemic
2022
Multi-center
Duration
Clinical Study
2023
SMILE
Study
2024
Pivotal
Clinical Trial